d8-THC
THC's gentler isomer
Cannabinoid
What is delta-8-THC?
Delta-8-THC (d8-THC) is a close chemical cousin of delta-9-THC — the double bond that defines them sits at a different position in the molecule. It occurs naturally in cannabis only in trace amounts, so most commercial d8-THC is made by converting CBD — typically hemp-derived — through a chemical process called isomerization.
Effects
Users generally describe d8-THC as milder than d9-THC — a gentler, less anxious intoxicating effect — though individual response varies widely and it still shows up on a drug test. A 2022 review in the British Journal of Pharmacology summarizes what's known: d8-THC is a partial agonist at CB1 with roughly half to two-thirds of d9-THC's potency, and early evidence points to the same kind of anti-nausea and appetite effects at lower strength.
How to read it on a COA
If you see d8-THC on a report, it's usually a sign the product was formulated with converted hemp-derived distillate rather than plain flower, where d8 is essentially negligible. As with any converted product, transparency about the process matters.
Conditions that cite this compound
These condition guides point here — they cover the same compound from the patient side.